Category Archives: News about GLYcoDiag

Micro-challenge test upgraded by GLYcoDiag

As you know GLYcoDiag provides it’s micro-challenge test services from more than 10 years. Compared to the standard method, the GLYcoDiag’s micro-challenge test is a high throughput, cost effective and the method of choice for research projects aiming at the discovery of new preservatives or the control steps of anti-microbial efficacy where the regulatory method is not absolutely required.

Now, we propose two additional upgraded models of our micro-challenge test method.

(1) Re-challenge testing. Repeated inoculation with specific test micro-organisms can show the number of contamination challenges a product can withstand before the preservative system fails for the micro-organism studied. The rechallenge testing consists of consecutive inoculation of a product (t=0h, 24h, 48h and 72h) and sampling after 24h, 48h, 72h, 7, 14, 21 and 28 days to determine preservative antimicrobial activity.

(2) Mixed. In this study, the goal is to compare the efficiency of a preservative with a mixture of microbial strains (i.e. Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 8739, Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404) and not only in a mono-culture. The mixed testing consists of a single inoculation of the product to be analysed (t=0h) with a mixture of microorganisms (fungi and bacteria) followed by sampling after 24h, 48h, 72h, 7, 14, 21 and 28 days to determine preservative antimicrobial activity, regarding fungi and/or bacteria, in a more complex environment model.

In addition, we have more than 40 different laboratory strains in our microbiological bank as well as more than 10 wild-type strains (from human skin) that you can choose and use for the research of microbiological properties of your product. This strains were all adapted and validated in our micro-challenge test methods.

In cosmetics Global – Stand P105 – Paris 5-7 April 2022

Book in your calendar!!! GLYcoDiag will be present in the next In Cosmetics global 2022 in Paris porte de Versailles from Tuesday 5th to Thursday 7th April 2022 (Stand P105). GLYcoDiag will present the full services intended to microbiote studies and its technology platform GLYcoPROFILE®, intended to the research of new active products and the study of « glyco-actives » mechanisms relevant for cosmetic applications, which allow to reduce your time development and increase your innovation capability. Contact us to book a B2B meeting with us.

GLYcoPROFILE used in bacterial studies of Tropheryma whipplei infection

Divoly, A., Zarza, S. M., Landemarre, L., Roubinet, B., Decloquement, P., Raoult, D., Fournier, P.-E., Desnues, B. Human galectin-1 and galectin-3 promote Tropheryma Whipplei infection, Gut microbes, 2021, 13, e1884515 (DOI : 10.1080/19490976.2021.1884515).


GLYcoPROFILE was recently used for the characterization of Tropheryma whipplei, an actinobacterium which causes various infections in humans, including Whipple’s disease. Thus, the GLYcoPROFILE has enabled to characterize the glycan signature of T. Whipplei glycoproteins.