Microbiota & Glyco-Microbiota

Since 2009, GLYcoDiag develop large expertise in applied microbiology starting with miniaturized alternative methods, them innovative. We offers services in microbiology in order to help our customers (mainly in cosmetics and nutraceutics fields) in the research and optimisation of new ingredients acting on the microbiome.

You target activity of your ingredients as either prebiotics ; microbiota “neutral label” ; restore microbiota equilibrium ; microbiota enzymatic activity ; or on the contrary activity against micro-organisms like new systems preservatives ; boosters or validation of the efficacy of new preservatives formulations, we can help you.

GLYcoDiag specialized in glycobiology and microbiota services, can help you to determine the action of your product on the growth, the death, the adhesion of microorganisms and their communication with cells (human skin and/or intestinal cells):

• Co-culture system(s) : Ingredient activities on skin microbiota can be demonstrated on specific co-culture models mimicking skin environments, in order to know the ability of your product to modulate: (1) diversity and growth of microbiota, (2) adhesions of respective microbial strains on skin cells, (3) protect microbiota from environmental stresses (UV, pollution).

 

• Design of new systems preservatives : Our famous micro-challenge test method can be specifically customized according to your needs. From high throughput screening for antimicrobials activities to the design of boosters, systems preservatives or optimization of synergy effects. Moreover, adapted to various creams viscosities, the micro-challenge test can help you to accelerate your development through large screening with different formulations.

 

• Antimicrobial activities : GLYcoDiag miniaturized methods help you to screen a number of compounds on a large range of bacteria and fungi (list available upon request) in order to determine the corresponding minimal inhibitory concentration (CMI) and eventually bactericidal inhibitory concentration (CMB) if needed, for each product or combinations of products. Alternatively, Time kill study can give you more details about the kinetics of antimicrobial action of your product.

 

• Prebiotics properties : GLYcoDiag has developed a specific method intended for the determination of microorganisms growth (validated on a large range of bacteria and fungi). Growth activation is assessed in comparison with minimal and optimal growth controls.