Category Archives: News about GLYcoDiag

FimH LEctPROFILE kit enables to screen and study new FimH ligands based on cellulose derivatives.

Cauwel, M.; Sivignon, A.; Bridot, C.; Nongbe, M. C.; Deniaud, D.; Roubinet, B.; Landemarre, L.; Felpin, F.-X.; Bouckaert, J.; Barnich N.; Gouin, S. G.; Chem. Commun., 2019, 55, 10158-10161 .

The development of a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains was studied. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. FimH LEctPROFILE plates was used in this study to evaluate the effect of the mannose-grafted cellulose compound over FimH lectin.

Neoglycoclusters

Neoglycoproteins are glycosylated bovine serum albumin (BSA) molecules. In order to improve accessibility and avidity of a carbohydrate-binding proteins, a new version of neoglycoproteins containing spacer arm (i.e. an alkyl spacer or a polyethylene glycol (PEG) chain), were developped and proposed either with monosaccharides/disaccharides or with glycoclusters.

Musa acuminata (BanLec) lectin an original Mannose binding lectin

Musa acuminata lectin (BanLec) is isolated from banana pulp and purified by affinity column chromatography on CarbPROFILE Mannose (see below the focus on GLYcoDiag affinity gel). The  carbohydrate recognition domain of BanLec is mainly specific for mannose. BanLec is available in 2 to 5 mg unlabelled or labelled with biotin or fluorescein.

GLYcoDiag lectin BanLec v1.1

GLYcoPROFILE® makes the news! GLYcoPROFILE was used by Seqens and reported in In-Cosmetics 2019

GLYcoDiag is pround to report that its technology of GLYcoPROFILE® have recently allowed to highlight glycobiological interactions of the cosmetic active Glycuron™ 2.78, developed by Seqens. Thanks to the curious and innovative team spirit of Seqens and their kind attention for mentionning GLYcoDiag through their communication.
Learn more about GLYcoPROFILE

GLYcoDiag will be attending In-cosmetics, Paris, 2-4 april 2019

Heading into its 30th edition in 2019, in-cosmetics Global is the leading event for personal care ingredients. The exhibition brings together personal care ingredients suppliers (exhibitors) with finished product manufacturers (visitors), each looking to network, learn about future trends, and discover new products.

We are pleased to invite you to meet us on our booth and discuss about our glycosciences and microbiote services and innovation strategies:

We provide added value in terms of innovation, originality and scientific proofs for the research and development of “glycoactives”

– Our technology platform GLYcoPROFILE® is intended for biological activities prediction through the study of skin cells, microbiote and involvement of glycosylated molecules in the natural glycobiological interactions relevant for cosmetics applications.

– High throughput and/or alternative methods aimed to study microbiote activities of products. Activities comparison on various strains (either isolated or mixed in co-culture models. Prebiotics or, on the contrary, anti-microbials effects.

– Microbiote / glycobiological interactions studies. As a research company specialized in Glycosciences, we have a strong know-how regarding the interactions between microbiote and cutaneous cells mediated by lectins (lectins-like)-glycoconjugates recognitions.