The Glycosciences products catalogue 2019 are now available to download.
Cauwel, M.; Sivignon, A.; Bridot, C.; Nongbe, M. C.; Deniaud, D.; Roubinet, B.; Landemarre, L.; Felpin, F.-X.; Bouckaert, J.; Barnich N.; Gouin, S. G.; Chem. Commun., 2019, 55, 10158-10161 .
The development of a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains was studied. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. FimH LEctPROFILE plates was used in this study to evaluate the effect of the mannose-grafted cellulose compound over FimH lectin.
GLYcoDiag is beneficiary of the LectARRAY ANR project (PRCE) in collaboration with CERMAV (project coordinator: Dr. Varrot), DCM (Dr Renaudet) and IBS (Pr. Fieschi) institutes. LectARRAY aim to developp lectin array applications for glycoanalysis of biopharmaceuticals.
Neoglycoproteins are glycosylated bovine serum albumin (BSA) molecules. In order to improve accessibility and avidity of a carbohydrate-binding proteins, a new version of neoglycoproteins containing spacer arm (i.e. an alkyl spacer or a polyethylene glycol (PEG) chain), were developped and proposed either with monosaccharides/disaccharides or with glycoclusters.
Musa acuminata lectin (BanLec) is isolated from banana pulp and purified by affinity column chromatography on CarbPROFILE Mannose (see below the focus on GLYcoDiag affinity gel). The carbohydrate recognition domain of BanLec is mainly specific for mannose. BanLec is available in 2 to 5 mg unlabelled or labelled with biotin or fluorescein.
GLYcoDiag is pround to report that its technology of GLYcoPROFILE® have recently allowed to highlight glycobiological interactions of the cosmetic active Glycuron™ 2.78, developed by Seqens. Thanks to the curious and innovative team spirit of Seqens and their kind attention for mentionning GLYcoDiag through their communication.
Learn more about GLYcoPROFILE
Heading into its 30th edition in 2019, in-cosmetics Global is the leading event for personal care ingredients. The exhibition brings together personal care ingredients suppliers (exhibitors) with finished product manufacturers (visitors), each looking to network, learn about future trends, and discover new products.
We are pleased to invite you to meet us on our booth and discuss about our glycosciences and microbiote services and innovation strategies:
– We provide added value in terms of innovation, originality and scientific proofs for the research and development of “glycoactives”
– Our technology platform GLYcoPROFILE® is intended for biological activities prediction through the study of skin cells, microbiote and involvement of glycosylated molecules in the natural glycobiological interactions relevant for cosmetics applications.
– High throughput and/or alternative methods aimed to study microbiote activities of products. Activities comparison on various strains (either isolated or mixed in co-culture models. Prebiotics or, on the contrary, anti-microbials effects.
– Microbiote / glycobiological interactions studies. As a research company specialized in Glycosciences, we have a strong know-how regarding the interactions between microbiote and cutaneous cells mediated by lectins (lectins-like)-glycoconjugates recognitions.
synBIOcarb “Synthetic biology of carbohydrate-binding proteins: engineering protein-carbohydrate interactions for diagnostics and cell targeting”
The synBIOcarb European Training Network brings together a diverse team of chemists, structural biologists, biophysicists, cell biologists and protein engineers who are pioneering the development of Synthetic Glycobiology, and four SMEs that are leading industrial innovation in glycoscience and protein engineering.
Together, we will provide 15 early stage researchers (ESRs) with advanced scientific training in enabling technologies that underpin the development and exploitation of glycoscience for diagnostics and targeted drug delivery. Each ESR will contribute to one, or more, of four thematic Work Packages, that have been designed to progress the state-of-the-art in Synthetic Glycobiology.
Practical scientific training will be complemented by a coordinated programme of industry-relevant transferable skills, that will prepare the ESRs for future careers in the medical technologies sector.
Currently a position for an early stage researcher is open at GLYcoDiag:
ESR Position: Development of lectin kit for quality control in production of recombinant glycoprotein
Applications are invited for a 36 months position as early-stage researcher (ESR) to work on the Marie Skłodowska-Curie Innovative Training Network synBIOcarb (Synthetic biology of carbohydrate-binding proteins: engineering protein-carbohydrate interactions for diagnostics and cell targeting; https://synbiocarb.science ).
The research, which will be carried out at GLYcoDiag, Orléans, France revolves around the development of a lectin chip covering the detection of the major undesirable glycan structures in therapeutic glycoproteins to allow real-time monitoring and control. We will clone, express and purify several lectins that have been reported in the literature to present the specificity toward glycan epitopes that may rise to unwanted immune response in production of glycosylated biopharmaceutical. Technology for biosensors will be investigated with partners.
The successful candidate will participate in the network’s training activities and work placements at the laboratories of the participating academic and industrial teams (secondments planned in three other laboratories located in Denmark, Slovakia and France). Regular meetings and workshops within the EU-funded synBIOcarb International Training Network will supplement the training and support provided at GLYcoDiag. Moreover, The early-stage researcher will be recruited as PhD Student at GLYcoDiag and will be registered at the doctoral school of University of Orléans.
Applicants should meet the following eligibility criteria:
– Have a Diploma and/or a Master Degree in biochemistry/organic chemistry. Previous knowledge or experience in glycobiology is desirable.
– Have less than 4 years research experience at the signature of the contract (measured from the time the Master’s degree has been obtained).
– Not have a PhD already.
– Not have resided or carried out main activity in France for more than 12 months in the last 3 years immediately prior to the reference recruitment date.
– Excellent knowledge of the English language (spoken and written / proficiency level)
– A particular experience and/or interest for applied research and working in environment of small biotech company would be an advantage.
The ESR will be contractually employed by GLYcoDiag and will be covered under the social security scheme. He or she will receive a Monthly Living Allowance plus a Mobility Allowance compliant with the applicable EC Marie Skłodowska-Curie Actions-ITN general conditions.
Candidates should submit a CV, cover letter and the names and contact details of at least 3 references by e-mail to email@example.com indicating reference nº ITN1810 in the subject.