Download the GLYcoDiag’s Newsletter March 2020 about the development of NeuGc specific lectin HPyL and the potential applications.
Download the GLYcoDiag’s Newsletter February 2020 to learn more about GLYcoPROFILE, a method used to predict potential biological activities.
Download the GLYcoDiag’s Newsletter January 2020 about the recombinant prokaryotic lectins (RPLs) from GlycoSeLect.
The Glycosciences products catalogue 2019 are now available to download.
Cauwel, M.; Sivignon, A.; Bridot, C.; Nongbe, M. C.; Deniaud, D.; Roubinet, B.; Landemarre, L.; Felpin, F.-X.; Bouckaert, J.; Barnich N.; Gouin, S. G.; Chem. Commun., 2019, 55, 10158-10161 .
The development of a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains was studied. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. FimH LEctPROFILE plates was used in this study to evaluate the effect of the mannose-grafted cellulose compound over FimH lectin.
GLYcoDiag is beneficiary of the LectARRAY ANR project (PRCE) in collaboration with CERMAV (project coordinator: Dr. Varrot), DCM (Dr Renaudet) and IBS (Pr. Fieschi) institutes. LectARRAY aim to developp lectin array applications for glycoanalysis of biopharmaceuticals.
Neoglycoproteins are glycosylated bovine serum albumin (BSA) molecules. In order to improve accessibility and avidity of a carbohydrate-binding proteins, a new version of neoglycoproteins containing spacer arm (i.e. an alkyl spacer or a polyethylene glycol (PEG) chain), were developped and proposed either with monosaccharides/disaccharides or with glycoclusters.
Musa acuminata lectin (BanLec) is isolated from banana pulp and purified by affinity column chromatography on CarbPROFILE Mannose (see below the focus on GLYcoDiag affinity gel). The carbohydrate recognition domain of BanLec is mainly specific for mannose. BanLec is available in 2 to 5 mg unlabelled or labelled with biotin or fluorescein.
GLYcoDiag is pround to report that its technology of GLYcoPROFILE® have recently allowed to highlight glycobiological interactions of the cosmetic active Glycuron™ 2.78, developed by Seqens. Thanks to the curious and innovative team spirit of Seqens and their kind attention for mentionning GLYcoDiag through their communication.
Learn more about GLYcoPROFILE
Heading into its 30th edition in 2019, in-cosmetics Global is the leading event for personal care ingredients. The exhibition brings together personal care ingredients suppliers (exhibitors) with finished product manufacturers (visitors), each looking to network, learn about future trends, and discover new products.
We are pleased to invite you to meet us on our booth and discuss about our glycosciences and microbiote services and innovation strategies:
– We provide added value in terms of innovation, originality and scientific proofs for the research and development of “glycoactives”
– Our technology platform GLYcoPROFILE® is intended for biological activities prediction through the study of skin cells, microbiote and involvement of glycosylated molecules in the natural glycobiological interactions relevant for cosmetics applications.
– High throughput and/or alternative methods aimed to study microbiote activities of products. Activities comparison on various strains (either isolated or mixed in co-culture models. Prebiotics or, on the contrary, anti-microbials effects.
– Microbiote / glycobiological interactions studies. As a research company specialized in Glycosciences, we have a strong know-how regarding the interactions between microbiote and cutaneous cells mediated by lectins (lectins-like)-glycoconjugates recognitions.