Download the GLYcoDiag’s Newsletter March 2020 about the development of NeuGc specific lectin HPyL and the potential applications.
GLYcoDiag’s Newsletter February 2020
Download the GLYcoDiag’s Newsletter February 2020 to learn more about GLYcoPROFILE, a method used to predict potential biological activities.
GLYcoDiag’s Newsletter January 2020
Download the GLYcoDiag’s Newsletter January 2020 about the recombinant prokaryotic lectins (RPLs) from GlycoSeLect.
GLYcoDiag launches it first version of products catalogue
The Glycosciences products catalogue 2019 are now available to download.
FimH LEctPROFILE kit enables to screen and study new FimH ligands based on cellulose derivatives.
Cauwel, M.; Sivignon, A.; Bridot, C.; Nongbe, M. C.; Deniaud, D.; Roubinet, B.; Landemarre, L.; Felpin, F.-X.; Bouckaert, J.; Barnich N.; Gouin, S. G.; Chem. Commun., 2019, 55, 10158-10161 .
The development of a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains was studied. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. FimH LEctPROFILE plates was used in this study to evaluate the effect of the mannose-grafted cellulose compound over FimH lectin.
ANR project « LectARRAY »
GLYcoDiag is beneficiary of the LectARRAY ANR project (PRCE) in collaboration with CERMAV (project coordinator: Dr. Varrot), DCM (Dr Renaudet) and IBS (Pr. Fieschi) institutes. LectARRAY aim to developp lectin array applications for glycoanalysis of biopharmaceuticals.
Glycobiological interaction studies – a key for the understanding of exopolysaccharide behavior and biofilm formation.
Recently, the group of Parsek have published a study about the function of the exopolysaccharide (PsI) found in Pseudomonas aeruginosa and its interaction with the bacterial lectin LecB that induce stabilisation of the biofilm. This work justifies the interest of glycobiological interactions studies that enable to answer and explain some stayed unknown mecanisms up to now. The expertise of GLYcoDiag in this field is now well known through the GLYcoPROFILE technology platform which is adapted for bacteria-cells glycobiological interactions studies.
Passos da Silva, D., Matwichuk, M. L., Townsend, D. O., Reichhardt, C., Lamba, D., Wozniak, D. J., Parsek, M. R., Nat. Comm., 2019, 10, 2183 (DOI : 10,1038/s41467-019-10201-4)
Neoglycoclusters
Neoglycoproteins are glycosylated bovine serum albumin (BSA) molecules. In order to improve accessibility and avidity of a carbohydrate-binding proteins, a new version of neoglycoproteins containing spacer arm (i.e. an alkyl spacer or a polyethylene glycol (PEG) chain), were developped and proposed either with monosaccharides/disaccharides or with glycoclusters.
30th Glycobiology meeting (JGM) at Villeneuve d’Ascq
Glycodiag support the 30th Glycobiology meeting (JGM) at Villeneuve d’Ascq from 27th to 29 October 2019. If you want to participate visit the following website.
Musa acuminata (BanLec) lectin an original Mannose binding lectin
Musa acuminata lectin (BanLec) is isolated from banana pulp and purified by affinity column chromatography on CarbPROFILE Mannose (see below the focus on GLYcoDiag affinity gel). The carbohydrate recognition domain of BanLec is mainly specific for mannose. BanLec is available in 2 to 5 mg unlabelled or labelled with biotin or fluorescein.
