Download the GLYcoDiag’s Newsletter January 2021 about α2.3/α2.6 Neoglycoproteins.
The Glycosciences products catalogue 2021 are now available to download.
Polyvalent transition‐state analogues of sialyl substrates strongly inhibit bacterial sialidases.
C. Assailly, C. Bridot, A. Saumonneau, P. Lottin, B. Roubinet, E-M. Krammer, F. François, F. Vena, L. Landemarre, D. Alvarez Dorta, D. Deniaud, C. Grandjean, C. Tellier, S. Pascual, V. Montembault, L. Fontaine, F. Daligault, J. Bouckaert, S. G. Gouin., A., Chem. Eur. J., 2020, (DOI : 10.1002/chem.202004672).
GLYcoPROFILE technology was recently used in bacterial sialidases studies to screen a large range of inhibitors. Trough this method, polyvalent compounds based on the transition state sialyl cation 2-deoxy-2,3-didehydro-N-acetylneuraminic (DANA) have shown high affinity for sialidase from S.pneumoniae (NanA) from micromolar to picomolar range.
GLYcoPROFILE technology is an useful tool for characterisation of new ligands. A range of LEctPROFILE kits developed by GLYcoDiag are coming soon for your research needs (i.e. Sialylation (NeuAc, NeuGc, α2,3/α2,6), Galili, DC-SIGN & Langerin, …).
Download the GLYcoDiag’s Newsletter November 2020 about LEctPROFILE and CarbPROFILE gels.
Download the GLYcoDiag’s Newsletter October 2020 about Neoglycoproteins NeoGalf and NeoGalili.
Laminarin Effects, a β-(1,3)-Glucan, on Skin Cell Inflammation and Oxidation
Ozanne, H., Toumi, H., Roubinet, B., Landemarre, L., Lespesailles, E., Daniellou, R., Cesaro, A., Cosmetics, 2020, 7, 66.
GLYcoPROFILE was recently used to evaluate on cutaneous cells (i.e. NHDFa and NHEK) the effect of Laminarin, a β-(1,3)-glucan from the seaweed Laminaria digitata, polysaccharide which provides anti-inflammatory and anti-oxidative properties.
This study is another example of the powerfull interest to use the GLYcoPROFILE technology to investigate biological properties of glycomolecules.
Download the GLYcoDiag’s Newsletter September 2020 about cells GLYcoPROFILE.
Download the GLYcoDiag’s Newsletter June 2020 about our original lectins (cMol, BanLec, TXLC-I and CorM)
Download the GLYcoDiag’s Newsletter May/June 2020 about our list of recombinant lectins.
Queiroz, A., Landemarre, L., Vial, F., Aubert, A., IFSCC Magazine 1 2020
The GLYcoPROFILE® study was used recently in the development of a new cosmetic ingredient developped by Seqens. This study highlights the ability of a high molecular weight exopolysaccharide to provide a quantifiable benefit versus placebo by visibly enhancing not only the quality of the skin tissue but also the consumer’s emotional state. In fact, the GLYcoPROFILE have enabled to highlight specific interaction with rhamnose specific lectin (lectin CorM which recognizes rhamnosylated glycan structures in the same manner as rhamnose-specific protein expressed at the surface of keratinocytes and fibroblasts). Apart from the fact that rhamnose glycan motif recognition is known to interfere with cells and epidermal regeneration, thus having anti-aging and anti-inflammatory properties, rhamnose recognition is known to enhance beta-endorphin release by keratinocytes and improve the feeling of wellbeing.