Lectins
Lectins are proteins or glycoproteins which possess the ability to bind specifically sugars. They have no enzyme activity and are not antibodies. Lectins are ubiquitous in nature, being found in all kinds of organisms (virus, microorganisms, plants, invertebrates and vertebrates). Lectins are usually oligomeric proteins and have many binding sites. The binding constant of the specific free sugar is generaly many orders of magnitude lower than the binding constant of a glycoconjugate (glycolipid, glycoprotein…) containing this sugar. Lectins agglutinate cells, some lectins are even blood type specific, but they are also able to recognise cells surface glycans allowing to distinguish between different cells species and states. Furthermore some lectins stimulate lymphocyte and induce mitosis.
The lectins have been used for :
- Studies of glycobiological interactions with glycans or glycans mimics
- Detection, isolation, and structural studies of glycoproteins
- Study the dynamics of the cell surface glycoconju gates
- Cell identification and to separate subpopulation of cells and subcellular organelles – Study endocytosis, neoplastic transformation
- Mitogenic stimulation of lymphocytes
- Glyco-biomarkers dicovery and new diagnostics assays design
Products quality
Home made lectins either purified from natural sources or cloned and produced in our laboratory
- Each lectin is carefully controled according to our specifications:
- Purity ≥ 90%
- Binding specificity (performed on a range of reference glycoproteins and neoglycoproteins)
- Avidity
- Each lectin is validated in our lectin array technology GLYcoPROFILE®
On request all lectins references can be labelled for :
- colorimetric readout
- fluorescent readout
Detailed product list:
Search into GLYcodiag's database the availability of your product :
Reference | Short Name | Common Name | Inhibitory Carbohydrate | Glycans Structures Specifities | |
---|---|---|---|---|---|
L1222 | ABA | Agaricus Bisporus | Gal/GalNAc | Gal(β-1,3) GaINAc | |
L1221 | AIA / Jacalin | Artocarpus intergrifolia | Gal | Galα1-6 or Galβ1-3GalNAc (T-antigen)>> lactose, more specific for T-antigen than PNA | |
L1367 | AML | Astragalus membranaceus | Gal | Galβ | |
L1205 | ASA | Allium sativum agglutinin | α(1,3)Man | Mannose | |
L1889 | BanLec | Musa acuminata | Mannose, Glucose | αMan | |
L1255 | BC2L-A | Burkholderia cenocepacia | α(1,3)Man | Mannose-containing ligands | |
L1256 | BC2L-C | Burkholderia cenocepacia | Lewis b / Lewis Y | Fucose containing ligands | |
L1254 | CJA | Crotalaria juncea | lactose | Gal > GalNAc | |
L1366 | cMol | Moringa oleifera | fetuin, thyroglobuline | GlcNAc, Complex carbohydrate-binding specificity | |
L1201 | Con A | Concanavalin A | MeαMan | α-Man, Glc | |
L1249 | CorM | Coregonus lavaretus marenae | Rhamnose | Rhamnose | |
L1688 | FimH | Escherichia coli adhesin | MeαMan | Mannose containing ligands | |
L1206 | GNA | Galanthus nivalis | MeαMan | (α-1,3) Man residues | |
L2094 | HPyL | Human Polyomavirus 9 VP1 | Neu5Gc | 5-N-glycolylneuraminic acid (Neu5Gc) | |
L1202 | LcH | Lens culinaris | MeαMan | Manα/Glcα > GlcNAcα, core GlcNAc of N-linked glycopeptides with a Fuc linked α6. | |
L1252 | NPA | Narcissus pseudonarcissus | α1,6 linked Mannosetriose > Methylmannoside. | External or internal α or β mannose. | |
L1257 | PAI-L, LecA | Pseudomonas aeruginosa | Gal | αGal | |
L1259 | PAII-L, LecB | Pseudomonas aeruginosa | αMeFuc | Fucose | |
L1240 | PHA-E | Phaseolus vulgaris | Gal, LacNAc | ß-D-Gal-(1-3)-D-GalNAc | |
L1239 | PHA-L | Phaseolus vulgaris | LacNAc | Galβ1-4GlcNAcβ1-6Man of branched structures of N-glycans, Galβ1-4GlcNAcβ1-2Man | |
L1223 | PNA | Arachis hypogaea | ßGal | ß-D-Gal(1-3)-D-galNAc | |
L1203 | PSA | Pisum sativum | αMeMan | Manα/Glcα > GlcNAc α, core GlcNAc of N-linked glycopeptides with a Fuc linked α6. | |
L2099 | RPL-Fuc1 | Recombinant prokaryotic lectin RPL-Fuc1 | Fuc | Fuc | |
L1579 | RPL-Gal1 | Recombinant prokaryotic lectin RPL-Gal1 | βGal | βGal/LacNAc | |
L1580 | RPL-Gal2 | Recombinant prokaryotic lectin RPL-Gal2 | βGal | αGal/GalNAc | |
L1581 | RPL-Gal3 | Recombinant prokaryotic lectin RPL-Gal3 | αGal | αGal | |
L1582 | RPL-Gal4 | Recombinant prokaryotic lectin RPL-Gal4 | βGal | βGal, LacNac, Lex | |
L1584 | RPL-Man2 | Recombinant prokaryotic lectin RPL-Man2 | Man | Man | |
L2096 | RPL-Sia1 | Recombinant prokaryotic lectin RPL-Sia1 | Neu5Ac | α2,3-linked sialic acid (Neu5Ac) on N/O-linked glycans | |
L2097 | RPL-Sia2 | Recombinant prokaryotic lectin RPL-Sia2 | Neu5Ac | α2,3-linked sialic acid (Neu5Ac) on O-linked glycans | |
L2098 | RPL-Sia3 | Recombinant prokaryotic lectin RPL-Sia3 | Neu5Ac | α-linked sialic acid (Neu5Ac) | |
L2095 | RPL-αGal | Recombinant prokaryotic lectin RPL-αGal | αGal/GalNac | αGal/GalNAc | |
L1583 | RPL-αMan | Recombinant prokaryotic lectin RPL-αMan | Fuc/Man | Fuc, Man, Lea , Lex | |
L1258 | RSL | Ralstonia Solanacearum | MeFuc (KD = 7.3 107 M)1 | Fucosylated structures | |
L1216 | SBA | Glycine Max | N-acetylgalactosamine. | D-GalNAc | |
L1237 | SNA | Sambucus nigra | Sialic acid / lactose. | Neu5Ac α-2,6 Gal/GalNAc | |
L1476 | TJA-II | Trichosanthes japonica agglutinin II | lactose | Gal, GalNAc | |
L1261 | TxLC-I | Tulipa gesneriana agglutinin | complex carbohydrates | Gal, GalNAc | |
L1253 | VEA | Vicia ervilia | methylmannoside | Man>trehalose>Glc | |
L1204 | VFA | Vicia faba agglutinin | Mannose > Glucose > GlcNAc | Mannose > Glucose > GlcNAc | |
L1230 | WGA | Triticum vulgaris | GlcNAc | GlcNAc |