We are pleased to share a recent scientific publication resulting from collaborative work involving GLYcoDiag. (https://www.mdpi.com/2673-4176/6/4/99 )
This study demonstrates how defined chondroitin sulfate disaccharides can selectively inhibit Cathepsin S, a cysteine protease involved in inflammation, immune regulation and extracellular matrix remodeling.
This highlights the growing importance of glycosaminoglycan structure in controlling biological activity.
Interestingly, the results show that:
• very short sulfated oligosaccharides can retain biological activity
• the position of sulfation is critical for protein binding
• multivalent glyco-architectures dramatically enhance biological effects
These findings open new opportunities for:
- pharmaceutical approaches targeting inflammatory proteases
- dermocosmetic innovation in anti-aging and skin barrier modulation
- cosmetic actives targeting skin inflammation and matrix degradation
At GLYcoDiag, we help our partners explore these mechanisms by providing:
• advanced glycan–protein interaction analysis
• functional biological assays
• custom experimental models to evaluate polysaccharide bioactivity.
If you are developing glycan-based ingredients or biomimetic actives, we would be happy to discuss how our expertise could support your projects.