Further insights in the design of potent uropathogenic E.coli FimH antagonists

FimH LEctPROFILE® kit were used recently for the characterisation of several antagonist for the Uropathogenic Escherichia coli (UPEC) type-1 fimbrial adhesin (FimH). This work reports the synthesis of new FimH antagonists, which are alternatives for antibiotic therapies and prophylaxes against acute or recurrent urinary tract infections (UTIs) caused by UPECs. The ICs obtained for some of them are in the nanomolar range.