Lectin

Lectins are proteins or glycoproteins which possess the ability to bind specifically sugars. They have no enzyme activity and are not antibodies. Lectins are ubiquitous in nature, being found in all kinds of organisms (virus, microorganisms, plants, invertebrates and vertebrates). Lectins are usually oligomeric proteins and have many binding sites. The binding constant of the specific free sugar is generaly many orders of magnitude lower than the binding constant of a glycoconjugate (glycolipid, glycoprotein…) containing this sugar. Lectins agglutinate cells, some lectins are even blood type specific, but they are also able to recognize cells surface glycans allowing to distinguish between different cells species and states. Furthermore some lectins stimulate lymphocyte and induce mitosis.

The lectins have been used for :

– Studies of glycobiological interactions with glycans or glycans mimics

– Detection, isolation, and structural studies of glycoproteins

– Study the dynamics of the cell surface glycoconju­gates

– Cell identification and to separate subpopulation of cells and subcellular organelles

– Study endocytosis, neoplastic transformation

– Mitogenic stimulation of lymphocytes

– Design diagnostics assays

 

References of lectins currently available :

Short Name

Common name

Reference

Qty (mg)

AIA

Artocarpus intergrifolia

L1221-10

10

L1221-100

100

AML

Astragalus membranaceus

L1367-2

2

L1367-10

10

CJA

Crotalaria juncea

L1254-10

10

L1254-50

50

cMol

Moringa oleifera

L1366-2

2

L1366-10

10

ConA

Canavalia ensiformis

L1201-100

100

L201-250

250

L1201-1000

1000

GNA

Galanthus nivalis

L1206-5

5

LcH

Lens culinaris

L1202-10

10

L1202-25

25

L1202-100

100

L1202-100

1000

NPA

Narcissus pseudonarcissus Daffodil

L1252-10

10

L1252-50

50

PHA-E

Phaseolus vulgaris

L1240-5

5

PHA-L

Phaseolus vulgaris

L1239-2

2

L1239-10

10

PHA-M

Phaseolus vulgaris – Crude lectin

L1585C-25

25

L1585C-1000

1000

PHA-M

Phaseolus vulgaris – Pure lectin

L1585P-25

25

L1585P-1000

1000

PHA-P

Phaseolus vulgaris

L1586-5

5

L1585-10

10

PNA

Arachis hypogaea

L1223-10

10

L1223-50

50

PSA

Pisum sativum

L1203-10

10

L1203-25

25

L1203-100

100

SBA

Glycine max

L1216-10

10

L1216-50

50

SNA

Sambucus nigra

L1237-5

5

L1237-10

10

L1237-50

50

TJA-I

Trichosanthes japonica Agglutinin I

L1477-2

2

L1477-25

25

L1477-100

100

TJA-II

Trichosanthes japonica Agglutinin II

L1476-2

2

L1476-25

25

L1476-100

100

VEA

Vicia ervilia

L1253-10

10

L1253-50

50

WGA

Triticum vulgare

L1230-10

10

L1230-25

25

L1230-100

100

L1230-1000

1000